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Year : 2018  |  Volume : 1  |  Issue : 2  |  Page : 30-34

Clinical benefits of magnesium sulfate in management of acute organophosphorus poisoning

1 Department of Forensic Medicine and Clinical Toxicology, Cairo University, Egypt
2 Department of Forensic Medicine and Clinical Toxicology, Cairo University, Egypt; Department of Forensic Medicine and Clinical Toxicology, Princess Nourah Bint Abdulrahman University, Riyadh, KSA
3 Department of Pharmacology, Cairo University, Egypt
4 National Environmental Center of Toxicological Research- Cairo University, Egypt

Correspondence Address:
Dr. Samah F Ibrahim
Princess Nourah Bint Abdulrahman University, Riyadh

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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/sjfms.sjfms_5_18

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Background: Organophosphorus (OP) poisoning is a common health problem. Its diagnosis depends on clinical findings. The main treatment of OP poisonings is atropine and oximes. However, new adjunct therapy such as magnesium sulfate (MgSO4) has been introduced. Materials and Methods: To detect the effects of MgSO4, a case–control study was conducted on 100 patients intoxicated with OP compounds. All patients received standard care of treatment while half of them received MgSO4 given in a dose of 1 g/6 h for 24 h. Results: The given atropine and oximes doses, hospitalization period, and incidence of complications, especially cardiac arrhythmias, respiratory failure, and death were significantly reduced in Mg-treated group. Conclusion: Results suggest that magnesium could ameliorate OP toxic effects and could be considered in the management of patients intoxicated with these compounds.

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